Coronary Endothelial Dysfunction Precedes Heart Failure and Reduction of Coronary Reserve in Awake Dogs
Why the study?
Does coronary microembolization-induced heart failure alter endothelium-dependent regulation in the remote coronary vasculature in dogs?
Population
7 dogs chronically instrumented for measurement of systemic hemodynamics and coronary blood flow in a…
Comparison
Daily selective coronary microembolization via… vs Baseline/control state before embolization and…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Endothelial dysfunction may precede overt HF in this model; hypothesis-generating for early microvascular changes in human disease.
Structured PICO
Does coronary microembolization-induced heart failure alter endothelium-dependent regulation in the remote coronary vasculature in dogs?
P
Population
7 dogs chronically instrumented for measurement of systemic hemodynamics and coronary blood flow in a coronary microembolization-induced heart failure model
I
Intervention
Daily selective coronary microembolization via an implanted coronary catheter until hemodynamic and echocardiographic measurements showed heart failure
C
Comparator
Baseline/control state before embolization and development of heart failure
O
Outcome
Responses of coronary blood flow to acetylcholine, nitroglycerin, adenosine, and brief coronary occlusionssurrogate
This preclinical study demonstrates that coronary endothelial dysfunction precedes the development of overt heart failure and the reduction of coronary flow reserve.
Cite This Study
Knecht et al. (1997) studied this question.