Key result
Chronic coronary embolization in dogs significantly impaired LV diastolic relaxation, decreasing dP/dt(min) by 25% and increasing chamber stiffness by 62% (P<0.05).
Why the study?
Does chronic coronary microembolization induce left ventricular diastolic dysfunction in a canine model of heart failure?
Population
Conscious dogs with heart failure induced by chronic coronary microembolization
Comparison
Chronic coronary embolization via daily… vs Baseline (pre-CCE)
Design
Preclinical
Follow-up
24 +/- 4 days
Authors
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Animal data preclude practice change; extends canine embolization models to diastolic dysfunction and stiffness.
Does chronic coronary microembolization induce left ventricular diastolic dysfunction in a canine model of heart failure?
p-value: p=<0.05
Chronic coronary microembolization in dogs induces significant left ventricular diastolic dysfunction and increased chamber stiffness, associated with myocardial fibrosis.
Gill et al. (2006) studied Congestive heart failure. Chronic coronary embolization (CCE) was evaluated on Left ventricular diastolic function parameters (p=<0.05). Chronic coronary embolization in dogs significantly impaired LV diastolic relaxation, decreasing dP/dt(min) by 25% and increasing chamber stiffness by 62% (P<0.05).
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