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April 1, 1991AJP Heart and Circulatory Physiology

LV ejection fraction decreased from 64 +/- 2% at baseline to 21 +/- 1% at 3 months after the last embolization (P < 0.001).

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Why the study?

Does multiple sequential intracoronary embolizations with microspheres produce a stable model of chronic heart failure in dogs?

Population

20 closed-chest dogs

Comparison

Multiple sequential intracoronary embolizations… vs Baseline measurements (pre-embolization)

Design

Preclinical

Follow-up

3 months after the last embolization

Authors

HSHani N. SabbahHeart Failure & TransplantPSP. D. SteinHenry Ford Health SystemTKT KonoOsaka Medical and Pharmaceutical University

Discussion

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Overview

Supports canine microsphere embolization model for chronic HF research; leaves open translation to humans.

Key Points

  • This research aims to establish a canine model of chronic heart failure using multiple sequential intracoronary embolizations.
  • Twenty closed-chest dogs underwent three to nine intracoronary embolizations performed 1-3 weeks apart.
  • Embolization was stopped when left ventricular ejection fraction fell below 35%.
  • Postmortem examinations assessed myocardial conditions after the procedure.
  • Left ventricular ejection fraction decreased from 64% to 21% after 3 months (P < 0.001).
  • Left ventricular end-diastolic pressure increased from 6 to 22 mmHg (P < 0.001).
  • Plasma norepinephrine levels rose significantly from 332 to 791 pg/ml (P < 0.01).

Structured PICO

Does multiple sequential intracoronary embolizations with microspheres produce a stable model of chronic heart failure in dogs?

P
Population
20 closed-chest dogs
I
Intervention
Multiple sequential intracoronary embolizations with microspheres (three to nine embolizations performed 1-3 weeks apart)
C
Comparator
Baseline measurements (pre-embolization)
O
Outcome
Left ventricular ejection fraction and hemodynamic parameters at 3 months after the last embolizationsurrogate

Multiple sequential intracoronary embolizations with microspheres successfully produce a stable and reproducible canine model of chronic heart failure characterized by reduced ejection fraction and neurohormonal activation.

Cite This Study

Sabbah et al. (1991) studied this question.

synapsesocial.com/papers/6a1fe2953f3a87967f2e44f8https://doi.org/10.1152/ajpheart.1991.260.4.h1379
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