Key result
Ameroid constrictors induce severe global LV dysfunction in dogs, decreasing LV size change by ~50%.
Why the study?
The mechanism(s) of left ventricular dysfunction in chronic coronary artery disease remain controversial due to the lack of an appropriate animal model.
Population
Dogs with Ameroid constrictors placed on proximal coronary arteries
Comparison
Regional myocardial beds with and without decreased myocardial blood flow
Design
Preclinical study developing a canine model of chronic ischemic cardiomyopathy
Follow-up
Mean of 6 weeks
Authors
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Supports canine multivessel stenosis model for ischemic LV dysfunction research; leaves open translation to human disease mechanisms or therapies.
p-value: p=<0.001
This canine model of multivessel stenosis closely mimics human chronic ischemic LV dysfunction, demonstrating that regional dysfunction can occur with or without a decrease in myocardial blood flow.
Firoozan et al. (1999) studied Chronic ischemic cardiomyopathy. Placement of Ameroid constrictors on proximal coronary arteries vs. Baseline was evaluated on LV end-systolic size and percent change in LV size from end diastole to end systole (p=<0.001). Placement of Ameroid constrictors in dogs induced severe global LV dysfunction, with LV end-systolic size nearly doubling (P<0.001) and percent change in LV size decreasing by >50% (P<0.001).
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