What question did this study set out to answer?

This study aims to evaluate how acute regional myocardial ischemia affects left ventricular function in dogs.

March 1, 1970Circulation ResearchOpen Access

Effects of Acute Regional Myocardial Ischemia on Left Ventricular Function in Dogs

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Why the study?

Does acute regional myocardial ischemia alter left ventricular function in a canine model?

Population

40 anesthetized dogs

Comparison

Occlusion of the anterior descending coronary… vs Baseline (before occlusion)

Design

Preclinical

Follow-up

Acute (measurements taken 2 minutes after occlusion)

Authors

LELee P. EnrightKing's College London HHHamner HannahUniversity Medical Center RRRobert L. ReisMedical University of South Carolina

Discussion

Member takes

Implication

Maximum velocity may poorly index contractility during acute ischemia; leaves open its clinical utility pending human validation.

Key Points

This study aims to evaluate how acute regional myocardial ischemia affects left ventricular function in dogs.
40 anesthetized dogs were evaluated during occlusion of the anterior descending coronary artery.
Ventricular function curves, maximum dp/dt, and isovolumetric force-velocity curves were assessed during the experiment.
Repeated measures were conducted to assess reproducibility of ventricular function loss after occlusion.
Maximum loss of ventricular function observed 2 minutes after occlusion of the artery, with a progressive shift in force-velocity curves during occlusion.
Resting diastolic length-tension relations remained unaffected by the coronary artery occlusion.
Impairment in force-velocity relationships was evident during depressed function in every instance observed.

Structured PICO

Does acute regional myocardial ischemia alter left ventricular function in a canine model?

Population

40 anesthetized dogs

Intervention

Occlusion of the anterior descending coronary artery 2 to 3 cm distal to its origin

Comparator

Baseline (before occlusion)

Outcome

Left ventricular function assessed via ventricular function curves, maximum dp/dt, isovolumetric force-velocity curves, and peak systolic and resting diastolic length-tension curvessurrogate

In a canine model of acute myocardial ischemia, maximum velocity of contraction was unchanged despite depressed ventricular function, indicating it is a poor index of contractility in this setting.

Cite This Study

Enright et al. (1970) studied this question.

synapsesocial.com/papers/6a729a42e36a167817e3f70f https://doi.org/10.1161/01.res.26.3.307

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Effects of Acute Regional Myocardial Ischemia on Left Ventricular Function in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of Acute Regional Myocardial Ischemia on Left Ventricular Function in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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