Why the study?
Does acute regional ischaemia reduce global isovolumic contractility indices in anaesthetised dogs?
Does acute regional ischaemia reduce global isovolumic contractility indices in anaesthetised dogs?
Acute regional ischaemia involving at least 12-14% of left ventricular mass reduces global isovolumic contractility in a canine model.
Answers are grounded in this paper and cite their sources.
Regional ischemia threshold effects on global contractility in canines leave open human translation and clinical monitoring implications.
In anaesthetised, open-chest dogs, global isovolumic contractility indices were reduced by acute regional ischaemia involving 12 to 14% or more of left ventricular mass. These effects were not altered by controlled reduction of blood flow to the non-ischaemic region, but were exaggerated by isoprenaline during normal perfusion of the non-ischaemic region. The results were consistent with a contraction model characterised by simple reduction of the effective length of the contractile elements.
No takes yet. Share an insight, caveat, or question.
Goodyer et al. (1977) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: