Key result
Regional ischaemia resulted in a variable inotropic response (decreased in 44%, increased in 33% of dogs), whereas global ischaemia invariably decreased contractile tension.
Why the study?
Does regional versus global ischemia differentially affect myocardial contractility and oxygen balance in a canine model?
Does regional versus global ischemia differentially affect myocardial contractility and oxygen balance in a canine model?
Endogenous catecholamine release may cause a paradoxical increase in contractile force during regional, but not global, myocardial ischemia, a response limited by oxygen availability.
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Variable regional ischemic responses in dogs warrant caution against clinical extrapolation; leaves open mechanisms of paradoxical inotropy for human validation.
Furman et al. (1985) studied Myocardial ischaemia (n=43). Regional ischaemia vs. Global ischaemia was evaluated on Contractile tension. Regional ischaemia resulted in a variable inotropic response (decreased in 44%, increased in 33% of dogs), whereas global ischaemia invariably decreased contractile tension.
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