Key result
Global myocardial ischaemia in cats reduced mean arterial pressure and left ventricular pressure, whereas regional ischaemia increased sympathetic discharge and mean arterial pressure.
The extent of ischaemic myocardium determines the prevailing type of neural and haemodynamic response, mediated by the interaction of cardiac vagal and sympathetic afferents.
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Should not inform clinical ischaemia management; leaves open translation of vagal-sympathetic afferent interactions to humans.
Lombardi et al. (1984) studied Myocardial ischaemia (n=19). Occlusion of the left main ('global' ischaemia) coronary artery vs. Occlusion of distal left anterior descending ('regional' ischaemia) coronary artery was evaluated on Cardiovascular and sympathetic responses (MAP, LVP, LVdP/dtmax, sympathetic efferent impulse activity). Global myocardial ischaemia in cats reduced mean arterial pressure and left ventricular pressure, whereas regional ischaemia increased sympathetic discharge and mean arterial pressure.
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