Key result
Vagotomy in anesthetized cats resulted in a significant increase in splanchnic nerve activity from 12.9 to 24.4 impulses/sec during cardiogenic hypotension, demonstrating that vagal afferents inhibit baroreceptor-mediated sympathetic augmentation.
p-value: p=<0.05
Vagal afferents from the heart appear to inhibit the sympathetic augmentation normally mediated by arterial baroreceptors during cardiogenic hypotension.
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Baroreflexes may blunt SNA during coronary occlusion in cats; leaves open human relevance.
Shozo Koyama (1985) studied Cardiogenic hypotension (n=10). Vagotomy vs. Intact neuraxis was evaluated on Preganglionic splanchnic nerve activity (SNA) at 60 seconds after coronary occlusion (p=<0.05). Vagotomy in anesthetized cats resulted in a significant increase in splanchnic nerve activity from 12.9 to 24.4 impulses/sec during cardiogenic hypotension, demonstrating that vagal afferents inhibit baroreceptor-mediated sympathetic augmentation.
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