The reflex cardiovascular depression caused by occlusion of the coronary sinus in the dog
Population
Open-chest anesthetized dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May caution against coronary sinus occlusion in procedures; leaves open translation of this vagal reflex to human interventions.
Structured PICO
P
Population
Open-chest anesthetized dogs
I
Intervention
Brief occlusions of the outflow from the cannulated coronary sinus
O
Outcome
Cardiovascular responses including coronary venous pressure, bradycardia, and systemic hypotensionsurrogate
Coronary sinus occlusion in dogs induces a reflex cardiovascular depression characterized by bradycardia and hypotension, mediated by vagal afferents from the ventricles.
Cite This Study
Muers et al. (1972) studied this question.