Why the study?
Does coronary sinus occlusion alter coronary hemodynamics and reduce ischemia-induced ventricular fibrillation in anesthetized open-chest dogs?
Population
Anesthetized open-chest dogs
Comparison
Coronary sinus occlusion using a specially… vs Baseline (pre-occlusion state)
Design
Preclinical
Authors
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Supports protective role of coronary sinus occlusion in canine ischemia; leaves open translation to human VF prevention.
Does coronary sinus occlusion alter coronary hemodynamics and reduce ischemia-induced ventricular fibrillation in anesthetized open-chest dogs?
Coronary sinus occlusion in a canine model alters coronary hemodynamics and reduces ischemia-induced ventricular fibrillation, suggesting a protective effect via retrograde flow.
Osamu Nishiyama (1984) studied this question.
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