Why the study?
Does transient occlusion of the coronary sinus alter the coronary pressure-flow relation in open-chest anesthetized dogs?
Population
Open-chest anesthetized dog preparations
Comparison
Transient occlusion of the coronary sinus vs Unoccluded state (baseline)
Design
Preclinical
Authors
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Challenges vascular waterfall model in dogs; leaves open applicability to human coronary pressure-flow relations.
Does transient occlusion of the coronary sinus alter the coronary pressure-flow relation in open-chest anesthetized dogs?
Elevation of coronary venous pressure increases zero-flow pressure without altering the slope of the coronary pressure-flow relation, challenging the vascular waterfall mechanism in the coronary circulation.
Bellamy et al. (1980) studied this question.
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