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August 1, 1984Circulation ResearchOpen Access

Arterial and venous coronary pressure-flow relations in anesthetized dogs. Evidence for a vascular waterfall in epicardial coronary veins.

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Key result

Coronary pressure manipulation in dogs reveals an epicardial vascular waterfall significantly influencing coronary blood flow.

Population

anesthetized dogs

Design

Preclinical

Authors

PUPaul N. UhligUniversity of KansasRBR. W. BaerA.T. Still UniversityGVGus J. VlahakesInterventional / Structural Cardiology

Discussion

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Implication

Animal data on venous waterfalls warrant caution before clinical extrapolation; leaves open their role in human coronary flow regulation.

Structured PICO

P
Population
Anesthetized dogs tested for the presence of vascular waterfalls by manipulating coronary arterial and coronary venous pressures.
I
Intervention
manipulation of coronary arterial and coronary venous pressures via cannulation
O
Outcome
relationships between coronary artery pressure, coronary sinus pressure, and coronary flowsurrogate

This preclinical study demonstrates the physiological presence of a vascular waterfall in epicardial coronary veins that influences coronary blood flow in a canine model.

Cite This Study

Uhlig et al. (1984) studied Coronary circulation physiology. Manipulation of coronary arterial and venous pressures was evaluated on Coronary pressure-flow relations. Manipulation of coronary pressures in anesthetized dogs demonstrated a vascular waterfall in epicardial coronary veins that significantly influences coronary blood flow.

synapsesocial.com/papers/6aa10e0c82859da7811a0dd4https://doi.org/10.1161/01.res.55.2.238
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of coronary sinus occlusion on coronary pressure-flow relations1980 · 56 citations
  2. 2Zero-Flow Pressures and Pressure-Flow Relationships during Single Long Diastoles in the Canine Coronary Bed before and during Maximum Vasodilation1981 · 73 citations
  3. 3The effects of the coronary capacitance on the interpretation of diastolic pressure-flow relationships.1982 · 72 citations
  4. 4Distribution of the Coronary Blood Flow across the Canine Heart Wall during Systole1974 · 144 citations
  5. 5Coronary Circulation in the Normal and the Pathologic Heart1968 · 152 citations