Why the study?
Does varying back pressure reveal a waterfall mechanism modulating flow into ischemic myocardium and across coronary collateral vessels in a canine model?
Population
16 dogs (two groups of 8) undergoing coronary artery ligation and cannulation to assess ischemic myocardium
Design
Preclinical
Authors
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Preclinical waterfall pressures should not guide care; leaves open translation of separate mechanisms to human ischemia and collaterals.
Does varying back pressure reveal a waterfall mechanism modulating flow into ischemic myocardium and across coronary collateral vessels in a canine model?
This preclinical study demonstrates that blood flow into ischemic myocardium and across coronary collateral vessels is modulated by separate waterfall mechanisms at critical pressures of approximately 10 mm Hg and 20 mm Hg, respectively.
Eng et al. (1984) studied this question.
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