Key result
Reducing left ventricular diastolic pressure from 9.3 to 3.5 mmHg increased mean retrograde blood flow from 7.3 to 9.3 ml/min, primarily mediated by the extravascular resistance mechanism.
Population
12 anesthetized dogs with cannulated left anterior descending coronary artery and completely embolized…
Comparison
Reduction of ventricular preload vs Baseline ventricular preload
Design
Preclinical
Authors
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Animal model links lower preload to greater collateral flow via extravascular resistance; leaves open human relevance.
Absolute Event Rate: 9.3% vs 7.3%
p-value: p=<0.05
In an animal model, extravascular resistance (the waterfall mechanism) mediates the coronary collateral flow response to a greater degree than intravascular resistance during variations in ventricular preload.
Conway et al. (1988) studied Coronary collateral blood flow (n=12). Reduction of ventricular preload vs. Baseline ventricular preload was evaluated on Retrograde blood flow (RBF) (p=<0.05). Reducing left ventricular diastolic pressure from 9.3 to 3.5 mmHg increased mean retrograde blood flow from 7.3 to 9.3 ml/min, primarily mediated by the extravascular resistance mechanism.
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