February 1, 1989AJP Heart and Circulatory Physiology
Pressure-flow characteristics of coronary collaterals in dogs
Key result
The free-flow method demonstrated a linear pressure-flow relationship with a pressure intercept of 1.7 +/- 1.2 mmHg, whereas the back-pressure method yielded a curvilinear relationship.
Population
16 dog hearts in a beating, blood-perfused, isolated heart preparation
Design
Preclinical
Authors
Discussion
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Implication
Method choice shapes coronary collateral pressure-flow curves; animal data leave open optimal technique for human translation.
Structured PICO
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Population
16 isolated dog hearts used to investigate the pressure-flow relationship of coronary collateral vessels.
I
Intervention
Measurement of pressure-flow relationship using free-flow method (varying perfusion pressure from 100 to 0 mmHg) and back-pressure method (varying back pressure from 0 to 100 mmHg, with and without embolization)
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Outcome
Pressure-flow relationship of coronary collateral vesselssurrogate
The method used to assess coronary collateral pressure-flow characteristics significantly influences the observed relationship, with back-pressure methods revealing curvilinear dynamics due to changes in coronary resistance.
Cite This Study
Scheel et al. (1989) studied Coronary collateral circulation (n=16). Free-flow method and back-pressure method was evaluated on Pressure-flow relationship and pressure intercept. The free-flow method demonstrated a linear pressure-flow relationship with a pressure intercept of 1.7 +/- 1.2 mmHg, whereas the back-pressure method yielded a curvilinear relationship.