What does this research mean for the field?

Zero-flow pressure (P(f=0)) is a quantitatively important determinant of coronary driving pressure and flow that substantially exceeds venous and ventricular diastolic pressures, and is influenced by both vasomotor tone and independent factors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1981Journal of Clinical InvestigationOpen Access

Zero-Flow Pressures and Pressure-Flow Relationships during Single Long Diastoles in the Canine Coronary Bed before and during Maximum Vasodilation

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Population

Open-chest canine preparation

Comparison

Pharmacologically induced maximum coronary… vs Before vasodilation (baseline state)

Design

Preclinical

Authors

FKFrancis J. KlockeCardiac Imaging IWIrwin R. WeinsteinErie County Medical Center JKJames F. KlockeErie County Medical Center

Discussion

Member takes

Implication

Zero-flow pressure substantially exceeds atrial pressure in coronary beds; leaves open its impact on human flow assessment and requires clinical validation.

Structured PICO

Population

Open-chest canine preparation

Intervention

Pharmacologically induced maximum coronary vasodilation

Comparator

Before vasodilation (baseline state)

Outcome

Zero-flow pressure (P(f=0)) and pressure-flow relationships during single long diastolessurrogate

Zero-flow pressure is a quantitatively important determinant of coronary driving pressure and flow, resulting from factors both related to and independent of vasomotor tone.

Cite This Study

Klocke et al. (1981) studied this question.

synapsesocial.com/papers/6a1be446c97d63156a5f1191 https://doi.org/10.1172/jci110351

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Implication

Zero-flow pressure substantially exceeds atrial pressure in coronary beds; leaves open its impact on human flow assessment and requires clinical validation.

Zero-Flow Pressures and Pressure-Flow Relationships during Single Long Diastoles in the Canine Coronary Bed before and during Maximum Vasodilation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Zero-Flow Pressures and Pressure-Flow Relationships during Single Long Diastoles in the Canine Coronary Bed before and during Maximum Vasodilation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider