What does this research mean for the field?

Mathematical modeling of the coronary circulation reveals that coronary sinus occlusion reduces total mean flow by 18% and partitions intramyocardial flow into distinct forward and backward components, requiring a non-linear pressure-volume relationship to accurately simulate venous distensibility. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1990Journal of Biomedical Engineering

Simulation of coronary circulation with special regard to the venous bed and coronary sinus occlusion

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Population

Computational model of the vascular beds of the left circumflex and left anterior descending coronary…

Comparison

Simulation of coronary sinus occlusion and… vs Simulation of normal coronary perfusion

Design

Preclinical

Authors

WSWolfgang SchreinerStatistics Austria FNFrank NeumannForma Therapeutics (United States)WMWerner MöhlMedical University of Vienna

Discussion

Member takes

Implication

Should not change practice; leaves open therapeutic relevance of flow effects from coronary sinus occlusion.

Structured PICO

Population

Computational model of the vascular beds of the left circumflex and left anterior descending coronary arteries (arterial, capillary, and venous sections) using coupled differential equations

Intervention

Simulation of coronary sinus occlusion and varying degrees of systolic myocardial squeezing

Comparator

Simulation of normal coronary perfusion

Outcome

Time courses of flows, volumes and pressures within large coronary arteries, capillaries and coronary veinssurrogate

A computational model predicts that coronary sinus occlusion reduces total mean flow by 18% and induces a backward component of intramyocardial flow, providing insights into therapeutically important but unmeasurable hemodynamic quantities.

Cite This Study

Schreiner et al. (1990) studied this question.

synapsesocial.com/papers/6a1bf1a8ea84844e355f3574 https://doi.org/10.1016/0141-5425(90)90029-m

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September 1, 1990Journal of Biomedical Engineering

Simulation of coronary circulation with special regard to the venous bed and coronary sinus occlusion

View Full Paper

Ask AI

Bookmark

Population

Computational model of the vascular beds of the left circumflex and left anterior descending coronary…

Comparison

Simulation of coronary sinus occlusion and… vs Simulation of normal coronary perfusion

Design

Preclinical

Authors

WSWolfgang SchreinerStatistics Austria FNFrank NeumannForma Therapeutics (United States)WMWerner MöhlMedical University of Vienna

Discussion

Member takes

Implication

Should not change practice; leaves open therapeutic relevance of flow effects from coronary sinus occlusion.

Structured PICO

Population

Computational model of the vascular beds of the left circumflex and left anterior descending coronary arteries (arterial, capillary, and venous sections) using coupled differential equations

Intervention

Simulation of coronary sinus occlusion and varying degrees of systolic myocardial squeezing

Comparator

Simulation of normal coronary perfusion

Outcome

Time courses of flows, volumes and pressures within large coronary arteries, capillaries and coronary veinssurrogate

Cite This Study

Schreiner et al. (1990) studied this question.

synapsesocial.com/papers/6a1bf1a8ea84844e355f3574 https://doi.org/10.1016/0141-5425(90)90029-m

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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