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August 24, 2005

Coronary Hemodynamics Simulated For The Normal State And During Therapeutic Interventions

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Population

Lumped parameter model of the coronary vasculature of the left ventricle

Comparison

Coronary sinus interventions vs Normal arterial perfusion

Design

Preclinical

Authors

WSWolfgang SchreinerFNFrank NeumannWMWerner Möhl

Discussion

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Overview

Informs computational models of coronary venous interventions; leaves open translation to human ischemia.

Structured PICO

P
Population
Lumped parameter model of the coronary vasculature of the left ventricle
I
Intervention
Coronary sinus interventions (coronary sinus occlusion)
C
Comparator
Normal arterial perfusion
O
Outcome
Coronary hemodynamics (oscillating flow and blood renewal in microcirculation)surrogate

A lumped parameter model demonstrates that coronary sinus occlusion can renew about two thirds of the blood stored in the microcirculation per cardiac cycle.

Cite This Study

Schreiner et al. (2005) studied this question.

synapsesocial.com/papers/6a1bf1a8ea84844e355f356chttps://doi.org/10.1109/iembs.1991.684891
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Simulation of coronary circulation with special regard to the venous bed and coronary sinus occlusion1990 · 12 citations
  2. 2Computer simulation of the coronary circulation: Implications for models and therapeutic Coronary Sinus Intervention1992
  3. 3The role of intramyocardial pressure during coronary sinus interventions: a computer model study1990 · 16 citations
  4. 4Simulations of fluxes and pressures including the time-dependence of the microvascular resistances in coronary three vessel disease2013
  5. 5Coronary three vessel disease: hydrodynamic simulations including the time-dependence of the microvascular resistances2014 · 2 citations