Why the study?
How does intramyocardial pressure impact intramyocardial flow during coronary sinus occlusion in a computer model?
Population
Computer model of the coronary circulation consisting of arterial, capillary, and venous compartments
Comparison
Variation of intramyocardial pressure under… vs Normal perfusion conditions and varying levels…
Design
Preclinical
Authors
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Hypothesis-generating for pressure-dependent retrograde perfusion; leaves open optimal intramyocardial targets in future sinus occlusion models.
How does intramyocardial pressure impact intramyocardial flow during coronary sinus occlusion in a computer model?
This computer model study suggests that retrograde flow during coronary sinus occlusion is biphasically dependent on intramyocardial pressure, peaking at moderate pressures and declining at very high pressures.
Schreiner et al. (1990) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: