July 1, 1990Cybernetics & Systems
Synchronized Retroperfusion Combined With Coronary Sinus Occlusion: Experimental Measurements Compared With Simulation Results and Model Predictions
Why the study?
Does synchronized retroperfusion combined with coronary sinus occlusion produce hemodynamic effects that match mathematical model predictions in dogs with coronary artery occlusions?
Population
Six open-chested dogs with coronary artery occlusions
Comparison
Synchronized retroperfusion of arterial blood… vs Mathematical model predictions
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Confirms model validity in canine coronary occlusion; leaves open translation to human synchronized retroperfusion.
Structured PICO
Does synchronized retroperfusion combined with coronary sinus occlusion produce hemodynamic effects that match mathematical model predictions in dogs with coronary artery occlusions?
P
Population
Six open-chested dogs with coronary artery occlusions
I
Intervention
Synchronized retroperfusion (SRP) of arterial blood into the coronary sinus at flow rates of 25, 50, 75, and 100 ml/min, with two modes of superimposed coronary sinus occlusion (mode 1: diastole only; mode 2: extended until plateau)
C
Comparator
Mathematical model predictions
O
Outcome
Aortic pressure, coronary venous pressure, and LAD pressure distal to the occlusionsurrogate
A mathematical model accurately predicts the hemodynamic effects of synchronized retroperfusion combined with coronary sinus occlusion in a canine model of coronary occlusion.
Cite This Study
Schreiner et al. (1990) studied this question.