This article summarizes computer simulation studies on the coronary circulation, focusing on the venous side and therapeutic coronary sinus interventions.
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Simulation summaries on coronary sinus interventions remain hypothesis-generating; prospective trials needed before any practice change.
The pulsatile blood flow through the coronary circulation of the human heart has been represented by a simulation model, with classes of blood vessels being lumped together into compartments. Blood flow within the heart muscle was obtained by numerically solving coupled differential equations. The model was particularly designed to represent the venous side of coronary circulation. Several issues, important for the effectiveness of therapeutic coronary sinus interventions, have been the subject of simulation studies in the past. The present article intends to provide a concise summary and discussion of these otherwise dispersed results. In addition to the conclusions regarding therapeutic effectiveness, several general aspects of modeling the coronary blood flow are addressed.
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Wolfgang Schreiner (1992) studied this question.
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