Key result
Introducing the time-dependence of coronary microvascular resistances into an analog electrical model allows for better representation of the effect of systolic ventricular contraction.
Population
Computational model of severe coronary three-vessel disease
Design
Preclinical
Authors
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May refine coronary flow models in severe disease; leaves open human validation for revascularization strategies.
Incorporating time-dependent microvascular resistances into coronary circulation models may improve the understanding of hemodynamics in severe coronary disease and revascularization strategies.
Harmouche et al. (2013) studied severe coronary disease (several stenoses on the left branches and total occlusion of the right coronary artery). Time-dependence of coronary microvascular resistances in an analog electrical model was evaluated on Fluxes and pressures in the coronary network. Introducing the time-dependence of coronary microvascular resistances into an analog electrical model allows for better representation of the effect of systolic ventricular contraction.
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