Key result
In isolated canine hearts, coronary sinus pressure elevation to 30 mmHg during cardiac contraction significantly increased regional myocardial blood flow in the ischemic LAD area (0.23 vs 0.19 ml/min/g; P<0.05).
Why the study?
Does coronary sinus pressure elevation combined with cardiac contraction improve regional myocardial blood flow in ischemic canine hearts?
Population
Seven isolated canine hearts with induced atrioventricular block and stopped left anterior descending…
Comparison
Coronary sinus pressure elevation to 30 mmHg… vs Normal coronary sinus pressure and/or nonbeating…
Design
Preclinical
Authors
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Does not support clinical use; leaves open whether coronary sinus pressure elevation augments ischemic perfusion in humans.
Does coronary sinus pressure elevation combined with cardiac contraction improve regional myocardial blood flow in ischemic canine hearts?
Absolute Event Rate: 0.23% vs 0.19%
p-value: p=< 0.05
Coronary sinus pressure elevation during cardiac contraction augments collateral flow to the periphery of ischemic myocardium in a canine model.
Sato et al. (1996) studied Ischemic myocardium (n=7). Coronary sinus pressure elevation to 30 mmHg (CS30) and cardiac contraction vs. Normal coronary sinus pressure and nonbeating heart was evaluated on Regional myocardial blood flow in the LAD perfused area (p=< 0.05). In isolated canine hearts, coronary sinus pressure elevation to 30 mmHg during cardiac contraction significantly increased regional myocardial blood flow in the ischemic LAD area (0.23 vs 0.19 ml/min/g; P<0.05).
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