What is the clinical evidence from this study?

Study design: Other. Intervention: Short-lasting occlusion of one coronary artery. Primary outcome: Circulatory responses (heart rate, blood pressure, resistance and capacitance vessel tone).

What question did this study set out to answer?

The study aims to understand the circulatory responses to coronary artery occlusions and the involvement of left ventricular receptors.

May 1, 1973Acta Physiologica Scandinavica

Evidence for a Depressor Reflex Elicited from Left Ventricular Receptors during Occlusion of One Coronary Artery in the Cat

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Key result

Acute occlusions of one coronary artery in cats induced a reflex bradycardia and vasodilatation, likely due to activation of left ventricular mechanoreceptors.

Population

Chloralose-anesthetized cats

Comparison

Short-lasting occlusions of one coronary artery vs Responses under different physiological conditions

Design

Preclinical

Authors

PTPeter ThorénCross-Cutting Cardiology

Discussion

Member takes

Implication

Baroreflex integrity attenuates feline coronary occlusion responses; leaves open human relevance pending clinical studies.

Key Points

The study aims to understand the circulatory responses to coronary artery occlusions and the involvement of left ventricular receptors.
Conducted in chloralose-anesthetized cats with coronary artery occlusions.
Assessed responses under varying conditions of baroreceptor function, including bilateral carotid occlusion.
Evaluated effects of cervical vagal block and local anesthetic administration.
Coronary occlusion caused pronounced reflex decreases in heart rate (bradycardia) and blood pressure.
When baroreceptor buffering was removed, vasodilatation was observed alongside the reflex bradycardia.
Influences from the cervical vagus and local anesthetics significantly reduced reflexive responses to coronary obstruction.

Structured PICO

Population

Chloralose-anesthetized cats undergoing short-lasting occlusions of one coronary artery.

Intervention

Short-lasting occlusions of one coronary artery (left anterior descendent or right coronary artery)

Comparator

Responses under different physiological conditions (intact baroreceptors, bilateral carotid occlusion, cold block of cervical vagi, i.v. lidocaine)

Outcome

Circulatory responses (heart rate, blood pressure, resistance and capacitance vessel tone)surrogate

Acute coronary occlusion in cats elicits a vagally-mediated depressor reflex (bradycardia and vasodilatation) originating from left ventricular mechanoreceptors.

Cite This Study

Peter Thorén (1973) studied this question. Short-lasting occlusion of one coronary artery was evaluated on Circulatory responses (heart rate, blood pressure, resistance and capacitance vessel tone). Acute occlusions of one coronary artery in cats induced a reflex bradycardia and vasodilatation, likely due to activation of left ventricular mechanoreceptors.

synapsesocial.com/papers/6a61cd1cf2fc5dc74fc1f5d7 https://doi.org/10.1111/j.1748-1716.1973.tb05430.x

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Bookmark

Evidence for a Depressor Reflex Elicited from Left Ventricular Receptors during Occlusion of One Coronary Artery in the Cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Evidence for a Depressor Reflex Elicited from Left Ventricular Receptors during Occlusion of One Coronary Artery in the Cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider