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June 1, 1966The Journal of PhysiologyOpen Access

The depressor reflex arising from the left coronary artery of the cat

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Population

Cats anaesthetized with pentobarbital or chloralose

Design

Preclinical

Authors

ABArthur BrownRutgers, The State University of New Jersey

Discussion

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Implication

Coronary pressure may elicit vagal depressor reflexes in anesthetized cats; leaves open relevance to conscious humans or clinical hemodynamics.

Structured PICO

P
Population
Cats anaesthetized with pentobarbital or chloralose
I
Intervention
Increased coronary artery pressure via perfusion from a pressurized reservoir and intracoronary injection of 1 mug veratridine
O
Outcome
Changes in sympathetic nerve discharge, blood pressure, and heart ratesurrogate

This preclinical study demonstrates that increased coronary artery pressure initiates a depressor reflex, likely via coronary mechanoreceptors with afferent fibers in the vagus nerves.

Cite This Study

Arthur Brown (1966) studied this question.

synapsesocial.com/papers/6a75a66827eb2deb12e8c5a6https://doi.org/10.1113/jphysiol.1966.sp007950
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TWO TYPES OF CORONARY VASOMOTOR REFLEXES1962 · 21 citations
  2. 2Evidence for Reflex Control of Arterial Pressure from Abdominal Receptors with Special Reference to the Pancreas1959 · 36 citations