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February 1, 1971The Journal of PhysiologyOpen Access

Spinal sympathetic reflexes initiated by coronary receptors

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Why the study?

Do increased coronary arterial pressure, coronary sinus occlusion, and myocardial ischaemia evoke reflex increases in sympathetic activity in vagotomized spinal cats?

Population

Vagotomized spinal cats

Design

Preclinical

Authors

ABArthur BrownRutgers, The State University of New JerseyAMAlberto MallianiElectrophysiology

Discussion

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Implication

Coronary stimuli elicit spinal sympathetic reflexes in cats; leaves open their contribution to human ischaemia syndromes.

Structured PICO

Do increased coronary arterial pressure, coronary sinus occlusion, and myocardial ischaemia evoke reflex increases in sympathetic activity in vagotomized spinal cats?

P
Population
Vagotomized spinal cats
I
Intervention
Perfusion of the main left coronary artery at different flows and pressures, coronary sinus occlusion, and myocardial ischaemia
O
Outcome
Changes in sympathetic discharge in the white ramus of the third thoracic spinal nerve and the inferior cardiac nervesurrogate

Increased coronary arterial pressure, coronary sinus occlusion, and myocardial ischemia excite coronary receptors that initiate excitatory spinal sympathetic reflexes.

Cite This Study

Brown et al. (1971) studied this question.

synapsesocial.com/papers/6a70c7ff31a3df82432905e2https://doi.org/10.1113/jphysiol.1971.sp009350
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The depressor reflex arising from the left coronary artery of the cat1966 · 37 citations
  2. 2Motor innervation of the coronary arteries of the cat1968 · 35 citations
  3. 3Excitation of afferent cardiac sympathetic nerve fibres during myocardial ischaemia1967 · 231 citations
  4. 4Distribution and Responses of the Cardiac Sympathetic Receptors to Mechanically Induced Circulatory Changes1969 · 60 citations
  5. 5Reflex discharges into thoracic white rami elicited by somatic and visceral afferent excitation1969 · 74 citations