Action potentials from ventricular mechanoreceptors stimulated by occlusion of the coronary sinus in the dog
Population
Open-chest anaesthetized dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May implicate ventricular receptors in systolic reflexes; hypothesis-generating for human studies.
Structured PICO
P
Population
Open-chest anaesthetized dogs (recordings from 69 single and small multi-fibre preparations of cardiac vagal afferents)
I
Intervention
Occlusion of the coronary sinus outflow, intrapericardial nicotine, catecholamines, sympathetic nerve stimulation, and aortic occlusion
O
Outcome
Action potential discharge from ventricular mechanoreceptors (epi-myocardial receptors)surrogate
Ventricular epi-myocardial receptors are stimulated by coronary sinus occlusion and catecholamines, suggesting they respond to systolic mechanical changes and may participate in cardiac reflexes.
Cite This Study
Muers et al. (1972) studied this question.