Key result
Independent stimulation of coronary mechanoreceptors decreased systemic vascular resistance by 40±2.5%, whereas large increases in ventricular pressure decreased resistance by only 9±2.2%.
Population
Anaesthetised dogs, artificially ventilated and placed on cardiopulmonary bypass
Design
Preclinical
Authors
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Coronary mechanoreceptors may predominate in reflex vasomotor control over ventricular ones; leaves open translation to human physiology and clinical relevance.
Coronary mechanoreceptors play a more significant role in cardiovascular reflex control than ventricular mechanoreceptors, which likely only function as a protective mechanism during gross distension.
Wright et al. (2000) studied this question. Independent stimulation of coronary and left ventricular mechanoreceptors was evaluated on Changes in systemic vascular resistance. Independent stimulation of coronary mechanoreceptors decreased systemic vascular resistance by 40±2.5%, whereas large increases in ventricular pressure decreased resistance by only 9±2.2%.
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