Occlusion of the main left coronary artery in cats reduced the Adelta elevation by 35-55%, indicating increased afferent activity in cardiac sympathetic nerve fibres during myocardial ischaemia.
Myocardial ischaemia from coronary occlusion excites afferent cardiac sympathetic nerve fibres, which likely signals pseudaffective responses.
Occlusion of the main left coronary artery of lightly anaesthetized cats provoked a pseudaffective reaction. The afferent pathway was in the cardiac sympathetic nerves.2. The compound action potential evoked in the inferior or middle cardiac nerves by stimulation of the thoracic sympathetic trunk contained two elevations, a small Adelta wave and a much larger sC wave. Occasionally a B wave was present.3. During coronary occlusion, the Adelta elevation was reduced by 35-55%, indicating afferent activity in these fibres. Multifibre preparations also showed increased afferent discharge during occlusion.4. It seems probable that the afferent activity in these fibres was mainly responsible for signalling the pseudaffective response elicited by coronary occlusion.5. Myocardial ischaemia produced by coronary occlusion was probably the stimulus for the increased activity.
Arthur Brown (1967) studied Myocardial ischaemia. Occlusion of the main left coronary artery was evaluated on Adelta elevation reduction. Occlusion of the main left coronary artery in cats reduced the Adelta elevation by 35-55%, indicating increased afferent activity in cardiac sympathetic nerve fibres during myocardial ischaemia.