Key result
Afferent signals and prior ischemic insults drive differential cardiac sympathetic reflexes during acute ischemia.
Why the study?
The mechanisms and reflex changes in cardiac sympathetic activities during acute myocardial ischemia and the influence of afferent fibers and previous ischemic insults were not fully understood.
Population
39 anesthetized dogs with left ventricular ischemia induced by coronary branch occlusion
Comparison
Selective afferent sympathectomy, vagotomy, epicardial phenol painting, or previous coronary occlusion
Design
Preclinical experimental study
Follow-up
30 minutes
Authors
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Ischemia-induced sympathetic reflex changes in canines warrant no clinical extrapolation; leaves open translation of afferent-driven effects to human arrhythmia risk.
In a canine model, both sympathetic and vagal afferent fibers participate in ischemia-induced cardio-cardiac reflexes, and prior ischemia alters the sympathetic reflex response.
Neely et al. (1990) studied Acute myocardial ischemia (n=39). Selective afferent sympathectomy, vagotomy, epicardial phenol painting, or previous coronary occlusion was evaluated on Cardiac sympathetic activities. Differential reflex changes in cardiac sympathetic activities during acute ischemia are driven by afferent signals from the ischemic region and influenced by previous ischemic insults.
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