Key result
Acute myocardial ischemia reduces local sympathetic activity ~15% while sparing nonischemic regions.
Why the study?
Regional cardiac sympathetic neural responses during acute myocardial ischemia and their dependence on ischemic location and nerve efferent destinations were not fully characterized.
Population
33 chloralose-anesthetized dogs
Comparison
Sympathetic activity during coronary occlusion vs control baseline
Design
Preclinical experimental study with electrical nerve stimulation and recording
Follow-up
30 minutes
Authors
Loading...
Differential sympathetic responses to regional ischemia are hypothesis-generating in dogs; leaves open translation to human autonomic modulation during acute MI.
p-value: p=<0.05
Acute myocardial ischemia in a canine model elicits differential sympathetic neural responses depending on the location of ischemia, characterized by decreased activity to ischemic regions and variable responses in nonischemic regions.
Neely et al. (1990) studied Acute myocardial ischemia (n=33). Left ventricular ischemia (LAD or LCX occlusion) vs. Baseline/control was evaluated on Cardiac postganglionic sympathetic efferent activities to ischemic and nonischemic myocardium (p=<0.05). In anesthetized dogs, acute myocardial ischemia decreased sympathetic activity to ischemic regions (84-87% of control) while activity to nonischemic regions was unchanged or increased.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: