Why the study?
Does brief myocardial ischemia alter sympathetic coronary vasoconstrictor responses in adult mongrel dogs?
Population
Adult mongrel dogs, anesthetized and instrumented
Comparison
Brief myocardial ischemia and reperfusion vs Baseline (before occlusion)
Design
Preclinical
Authors
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Brief ischemia may blunt sympathetic coronary vasoconstriction; leaves open translation to human ischemia-reperfusion or arrhythmia risk.
Does brief myocardial ischemia alter sympathetic coronary vasoconstrictor responses in adult mongrel dogs?
Brief myocardial ischemia (15 minutes) impairs sympathetic coronary vasoconstriction in the postischemic coronary arterial bed, though prejunctional norepinephrine release mechanisms appear intact.
Gutterman et al. (1992) studied this question.
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