Key result
During exercise, the subendocardial-to-subepicardial blood flow ratio was significantly higher in the innervated stenotic region compared to the sympathectomized region (0.60 vs 0.42, p<0.05).
Why the study?
Does sympathetic neural activation affect the transmural distribution of myocardial perfusion distal to a flow-limiting coronary artery stenosis during exercise?
Population
Conscious dogs with experimental flow-limiting coronary artery stenosis
Comparison
Treadmill exercise alone, with beta-adrenergic… vs Standing control conditions; intra-subject…
Design
Preclinical
Authors
Loading...
Sympathetic innervation may aid subendocardial perfusion during exercise with stenosis in this model; leaves open translation to human coronary disease.
Does sympathetic neural activation affect the transmural distribution of myocardial perfusion distal to a flow-limiting coronary artery stenosis during exercise?
Absolute Event Rate: 0.6% vs 0.42%
p-value: p=<0.05
Alpha-adrenergic coronary constriction distal to a flow-limiting stenosis facilitates redistribution of blood flow toward the subendocardium during exercise.
Chilian et al. (1988) studied Coronary artery stenosis. Sympathetic neural activation via treadmill exercise vs. Sympathectomized stenotic region was evaluated on Subendocardial-to-subepicardial blood flow ratio during exercise (p=<0.05). During exercise, the subendocardial-to-subepicardial blood flow ratio was significantly higher in the innervated stenotic region compared to the sympathectomized region (0.60 vs 0.42, p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: