Key result
Acute myocardial ischaemia in dogs increased regional wall stiffness in the ischaemic middle (14.2 vs 10.0; P<0.02) and apical segments, but not in the non-ischaemic basal segment.
Population
8 anaesthetized closed-chest dogs
Comparison
Acute myocardial ischaemia produced for 30 to 90… vs Control state prior to ischaemia
Design
Preclinical
Follow-up
30 to 90 seconds
Authors
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Acute ischaemia stiffens ischaemic segments in dogs; extends mechanistic insights but leaves open human translation.
Absolute Event Rate: 14.2% vs 10%
p-value: p=<0.02
Acute myocardial ischaemia increases regional myocardial wall stiffness in the ischaemic segments, likely related to changes in reference midwall circumference (creep).
Om et al. (1980) studied Acute myocardial ischaemia (n=8). Acute myocardial ischaemia (balloon-catheter inflation) vs. Control (baseline) was evaluated on Regional wall stiffness (Kn) in the middle segment (p=<0.02). Acute myocardial ischaemia in dogs increased regional wall stiffness in the ischaemic middle (14.2 vs 10.0; P<0.02) and apical segments, but not in the non-ischaemic basal segment.
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