May 1, 1985AJP Heart and Circulatory Physiology
Different effects of two types of ischemia on myocardial systolic and diastolic function
Population
21 anesthetized dogs with two-vessel critical coronary stenoses
Comparison
Pacing tachycardia vs Coronary occlusion in the same myocardial segment
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Distinguishes diastolic mechanics of demand versus supply ischemia in canines; leaves open translation to human angina.
Structured PICO
P
Population
21 anesthetized dogs with two-vessel critical (90%) coronary stenoses (n=14 for segment lengths, n=7 for LV wall thickness)
I
Intervention
Pacing tachycardia (ischemia due to increased O2 demand in the presence of coronary stenoses)
C
Comparator
Coronary occlusion (ischemia due to supply reduction) in the same myocardial segment
O
Outcome
Myocardial systolic and diastolic function (regional wall motion and segmental diastolic mechanics)surrogate
Demand ischemia (pacing with stenosis) and supply ischemia (occlusion) have substantially different effects on regional wall motion and segmental diastolic mechanics in a canine model.
Cite This Study
Paulus et al. (1985) studied this question.