March 1, 1980Circulation Research
Effect of pacing-induced ischemia on left ventricular diastolic pressure-volume relations in dogs with coronary stenoses.
Why the study?
Does pacing-induced ischemia alter left ventricular diastolic pressure-volume relations in a canine model with coronary stenoses?
Population
10 chloralose-anesthetized dogs with open chest and pericardium, with >90% proximal coronary artery stenoses…
Comparison
Pacing-induced ischemia vs Baseline state; and in a subset of 4 dogs, acute…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Caution against extrapolating canine ischemia effects to humans; leaves open translation of diastolic property changes to clinical practice.
Structured PICO
Does pacing-induced ischemia alter left ventricular diastolic pressure-volume relations in a canine model with coronary stenoses?
P
Population
10 chloralose-anesthetized dogs with open chest and pericardium, with >90% proximal coronary artery stenoses created in both left anterior descending and circumflex coronary arteries
I
Intervention
Pacing-induced ischemia (heart paced at nearly twice its resting rate, 115 ± 4 to 200 ± 5 beats/min)
C
Comparator
Baseline (pre-pacing) state; and in a subset of 4 dogs, acute right ventricular loading via pulmonary artery constriction and saline infusion
O
Outcome
Left ventricular diastolic pressure-volume relationssurrogate
Pacing-induced ischemia in a canine model shifts the LV diastolic pressure-volume curve upward independently of the pericardium, demonstrating that altered myocardial diastolic properties play a key role in ischemia-induced diastolic dysfunction.
Cite This Study
Serizawa et al. (1980) studied this question.