Key result
Pacing-induced ischemia shifted the diastolic pressure-volume curves upward in filling beats, whereas nonfilling beats fell on the fully relaxed pressure-volume relation of the normally perfused heart.
Why the study?
Does left ventricular filling contribute to the upward shift of the diastolic pressure-volume curve during pacing-induced ischemia in dogs?
Population
10 dogs using an in situ left ventricular volume clamping technique
Comparison
Pacing-induced ischemia with left ventricular… vs Normally perfused heart and nonfilling beats…
Design
Preclinical
Authors
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LV filling drives ischemic diastolic shifts in dogs; leaves open human translation and stretch-activation therapies.
Does left ventricular filling contribute to the upward shift of the diastolic pressure-volume curve during pacing-induced ischemia in dogs?
Left ventricular filling is necessary for the upward shift of the diastolic pressure-volume curve during pacing-induced ischemia, suggesting stretch activation or length-dependent changes in calcium sensitivity contribute to this phenomenon.
Shintani et al. (1994) studied Pacing-induced ischemia (n=10). Pacing-induced ischemia with filling beats vs. Normally perfused heart / nonfilling beats was evaluated on Diastolic pressure-volume curve shift. Pacing-induced ischemia shifted the diastolic pressure-volume curves upward in filling beats, whereas nonfilling beats fell on the fully relaxed pressure-volume relation of the normally perfused heart.
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