Key result
Induced regional ischemia during exercise in dogs markedly impaired early and overall diastolic LV filling, increasing minimal diastolic pressure by 4.84 mm Hg (p<0.005).
Why the study?
Does induced regional ischemia impair left ventricular diastolic function during exercise in a canine model?
Population
8 conscious dogs chronically instrumented with ultrasonic devices for measuring LV wall thickness and volume
Comparison
Treadmill exercise with induced regional ischemia vs Control treadmill exercise without ischemia
Design
Preclinical
Authors
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May impair exercise diastolic filling in ischemic hearts; leaves open translation to human coronary disease.
Does induced regional ischemia impair left ventricular diastolic function during exercise in a canine model?
p-value: p=<0.005
Regional ischemia during exercise markedly impairs early and overall diastolic left ventricular filling due to reduced relaxation rates, nonuniform wall motion, and impaired systolic function.
Miyazaki et al. (1990) studied regional ischemia (n=8). Induced regional ischemia during treadmill exercise vs. Control exercise without ischemia was evaluated on Left ventricular diastolic function (including minimal diastolic pressure [PDm]) (p=<0.005). Induced regional ischemia during exercise in dogs markedly impaired early and overall diastolic LV filling, increasing minimal diastolic pressure by 4.84 mm Hg (p<0.005).
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