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February 1, 1990Circulation ResearchOpen Access

During exercise, LVH dogs demonstrated a reduction in subendocardial wall thickening (-40 +/- 7%) and a fall in endocardial/epicardial flow ratio to 0.72 +/- 0.05 (p < 0.01), with dysfunction persisting into recovery.

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Why the study?

Does treadmill exercise induce subendocardial dysfunction and hypoperfusion in dogs with left ventricular hypertrophy?

Population

18 adult, conscious dogs

Comparison

Treadmill exercise to a target heart rate of 240… vs Control dogs without left ventricular…

Design

Preclinical

Authors

LHLuc HittingerRSRichard P. ShannonSKSuzanne Kohin

Discussion

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Overview

Raises concern for exercise-induced subendocardial stunning in LVH; leaves open translation from canine model to patients.

Structured PICO

Does treadmill exercise induce subendocardial dysfunction and hypoperfusion in dogs with left ventricular hypertrophy?

P
Population
18 adult, conscious dogs (10 with left ventricular hypertrophy induced by aortic banding in puppies, 8 control dogs)
I
Intervention
Treadmill exercise to a target heart rate of 240 beats/min
C
Comparator
Control dogs without left ventricular hypertrophy undergoing the same exercise protocol
O
Outcome
Regional myocardial blood flow and function (velocity of circumferential fiber shortening, shortening fraction, wall thickening)surrogate

In a canine model of left ventricular hypertrophy, exercise induces selective subendocardial hypoperfusion and dysfunction that persists into recovery, indicative of myocardial stunning.

Cite This Study

Hittinger et al. (1990) studied this question.

synapsesocial.com/papers/6a154b5779ff98d0de4e6586https://doi.org/10.1161/01.res.66.2.329
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial Blood Flow Distribution in Concentric Left Ventricular Hypertrophy1978 · 167 citations
  2. 2Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy.1981 · 40 citations
  3. 3Persistence of regional left ventricular dysfunction after exercise-induced myocardial ischemia.1986 · 147 citations
  4. 4Nonuniformity of inner and outer systolic wall thickening in conscious dogs1985 · 138 citations
  5. 5Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.1975 · 1,009 citations