Population
14 dogs
Comparison
Surgical shunt between the left subclavian… vs Sham operation
Design
Preclinical
Key result
Surgically induced volume overload and left ventricular hypertrophy in dogs increased stroke work per gram (P<0.005) and total left ventricular myocardial blood flow (P<0.05) versus sham operation.
Authors
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Preserved perfusion efficiency in compensated canine hypertrophy; hypothesis-generating and should not yet inform human practice.
p-value: p=<0.05
In a canine model, volume overload hypertrophy without heart failure is associated with normal myocardial blood flow per gram of tissue and normal flow distribution at rest and during exercise.
Hultgren et al. (1981) studied Chronic volume overload and left ventricular hypertrophy (n=14). Surgical shunt between the left subclavian artery and the left atrial appendage vs. Sham operation was evaluated on Myocardial blood flow and mechanics (p=<0.05). Surgically induced volume overload and left ventricular hypertrophy in dogs increased stroke work per gram (P<0.005) and total left ventricular myocardial blood flow (P<0.05) versus sham operation.
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