Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1981AJP Heart and Circulatory Physiology

Endocardial-to-epicardial blood flow ratios were reduced by 36% and 28% at maximal exercise and with adenosine, respectively (P < 0.05), which reversed upon fistula closure.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does volume-overload hypertrophy induced by aortocaval fistula alter regional myocardial perfusion in dogs?

Population

Dogs (experimental model)

Comparison

Aortocaval fistula for 12 weeks to induce… vs Sham-operated controls, and a subgroup evaluated…

Design

Preclinical

Follow-up

12 weeks

Authors

FBF R BadkeFWF. C. WhiteMWMoritz Winter

Discussion

Loading...

Member takes

Overview

Indicates subendocardial hypoperfusion in volume-overload hypertrophy is hemodynamically mediated; leaves open translation to human disease.

Structured PICO

Does volume-overload hypertrophy induced by aortocaval fistula alter regional myocardial perfusion in dogs?

P
Population
Dogs (experimental model)
I
Intervention
Aortocaval fistula for 12 weeks to induce volume-overload hypertrophy
C
Comparator
Sham-operated controls, and a subgroup evaluated before and after shunt closure
O
Outcome
Regional myocardial perfusion (myocardial blood flows measured with microspheres at rest, during exercise, and during exercise with adenosine infusion)surrogate

Subendocardial hypoperfusion in volume-overload hypertrophy is secondary to hemodynamic changes (low aortic diastolic pressure and high oxygen demand) rather than the hypertrophy itself.

Cite This Study

Badke et al. (1981) studied this question.

synapsesocial.com/papers/6a91afe605fd6a1e5860eebfhttps://doi.org/10.1152/ajpheart.1981.241.4.h564
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of chronic cardiac volume overload on regional myocardial blood flow in the dog1975 · 7 citations
  2. 2Myocardial blood flow in experimental cardiac hypertrophy in dogs1973 · 43 citations
  3. 3Cardiac vasculature and flow during pressure-overload hypertrophy1986 · 67 citations
  4. 4Myocardial blood flow and mechanics in volume overload-induced left ventricular hypertrophy in dogs1981 · 21 citations
  5. 5Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 2. Long-term effects.1991 · 78 citations