What question did this study set out to answer?

To investigate the effects of experimental myocardial hypertrophy on coronary blood flow and myocardial oxygen consumption.

July 1, 1973Cardiovascular Research

Myocardial blood flow in experimental cardiac hypertrophy in dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Does experimental cardiac hypertrophy alter coronary blood flow, myocardial O2 consumption, and coronary reserve capacity in dogs?

Population

26 unanaesthetized dogs

Comparison

Experimental myocardial hypertrophy produced by… vs Sham-operated dogs

Design

Preclinical

Follow-up

7 to 12 months

Authors

GMG. MarchettiUniversity of Pisa LML MerloSocietà Italiana di Cardiologia Interventistica VNV. NosedaUniversity of Milan

Discussion

Member takes

Implication

May predispose hypertrophied hearts to ischemia under stress; leaves open translation to human disease.

Key Points

To investigate the effects of experimental myocardial hypertrophy on coronary blood flow and myocardial oxygen consumption.
Conducted experiments with unanaesthetized dogs, with chronic electromagnetic flowmeters implanted.
Dogs were divided into hypertrophy (HI and H2) and sham-operated groups, with hypertrophy achieved via arteriovenous fistula production.
Measured coronary flow and oxygen consumption during rest and reactive hyperaemia.
Cardiac hypertrophy led to increased coronary blood flow and myocardial oxygen consumption at rest, with reduced coronary resistance.
Coronary reserve was significantly diminished in dogs with higher hypertrophy (H2), indicating reduced capacity for increased flow during stress.
Oxygen supply was normal at rest but may become inadequate under increased hemodynamic work.

Structured PICO

Does experimental cardiac hypertrophy alter coronary blood flow, myocardial O2 consumption, and coronary reserve capacity in dogs?

Population

26 unanaesthetized dogs (15 with systemic arteriovenous fistula producing cardiac hypertrophy, 11 sham-operated controls)

Intervention

Experimental myocardial hypertrophy produced by an arteriovenous fistula between the iliac vessels 7 to 12 months prior to experiments

Comparator

Sham-operated dogs

Outcome

Coronary blood flow, myocardial O2 consumption, and coronary reserve capacitysurrogate

Experimental cardiac hypertrophy in dogs leads to a reduction in coronary reserve capacity, potentially causing inadequate oxygen supply during increased hemodynamic work.

Cite This Study

Marchetti et al. (1973) studied this question.

synapsesocial.com/papers/6a70aa4d26770c2b8de0ab0f https://doi.org/10.1093/cvr/7.4.519

View Full Paper

Ask AI

Bookmark

Myocardial blood flow in experimental cardiac hypertrophy in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Myocardial blood flow in experimental cardiac hypertrophy in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider