Why the study?
Does left ventricular hypertrophy induced during normal body growth facilitate growth of coronary vasculature compared to hypertrophy induced in adulthood in dogs?
Population
24 dogs (8 young dogs 7 weeks of age, 9 adult dogs, and 7 normal control animals)
Comparison
Left ventricular hypertrophy produced by banding… vs Normal control animals
Design
Preclinical
Follow-up
2 months for adult dogs; until adulthood for young dogs
Authors
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LVH elevates minimal coronary resistance equally in young and adult dogs; leaves open whether vascular growth matches hypertrophy in patients.
Does left ventricular hypertrophy induced during normal body growth facilitate growth of coronary vasculature compared to hypertrophy induced in adulthood in dogs?
Growth of coronary vasculature does not appear to occur proportionally as the myocardium undergoes hypertrophy, regardless of whether the hypertrophy develops during normal body growth or in adulthood.
Bache et al. (1986) studied this question.
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