Why the study?
Does creation of a large aortocaval fistula alter hemodynamics and cardiac myocyte size in adult rats?
Does creation of a large aortocaval fistula alter hemodynamics and cardiac myocyte size in adult rats?
In a rat model of volume overload, increased cardiac mass at 5 months is driven by cellular hypertrophy rather than hyperplasia, with preserved or elevated cardiac function despite congestion.
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Informs mechanisms of volume-overload remodeling in rats; leaves open translation to human heart failure.
Liu et al. (1991) studied this question.
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