Population
15 open-pericardium anesthetized dogs (46 pacing-induced ischemia experiments)
Comparison
Pacing-induced ischemia vs Baseline and coronary stenosis conditions
Design
Preclinical
Authors
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Contractility dictates EDPVR shifts in canine ischemia; leaves open translation to human diastolic assessment.
In a canine model, left ventricular contractility is the primary determinant of how the end-diastolic pressure-volume relation shifts during pacing-induced ischemia.
Takano et al. (1995) studied this question.
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