Key result
In dogs with pacing-induced heart failure, high end-diastolic pressures result from geometric remodeling altering chamber compliance rather than stiffer myocardium, preventing elastic recoil.
Population
Anesthetized dogs with pacing-induced heart failure
Design
Preclinical
Authors
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Should not change clinical evaluation of diastolic HF; leaves open whether geometric remodeling drives human disease beyond animal models.
This study demonstrates that in pacing-induced heart failure, restrictive filling patterns result from geometric remodeling and loss of elastic recoil rather than intrinsic myocardial stiffening.
Solomon et al. (1998) studied Pacing-induced heart failure. Pacing-induced heart failure model was evaluated on Elastic properties of the myocardium and left ventricular chamber. In dogs with pacing-induced heart failure, high end-diastolic pressures result from geometric remodeling altering chamber compliance rather than stiffer myocardium, preventing elastic recoil.
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