Population
7 conscious dogs with experimental heart failure produced by rapid ventricular pacing
Comparison
Pharmacological intervention with dobutamine and… vs Baseline failing heart state
Design
Preclinical
Authors
Loading...
Highlights differential lusitropic effects in canine HF model; leaves open translation to human diastolic therapies.
In a canine model of pacing-induced heart failure, dobutamine improves early relaxation while the phosphodiesterase inhibitor E-1020 improves ventricular distensibility.
Sasayama et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: