Key result
Pacing-induced heart failure in dogs decreased beta-adrenergic receptor density (80 vs 122 fmol/mg, P<0.001), but maximum unloaded velocity of shortening normalized in response to isoproterenol.
Population
48 dogs with pacing-induced heart failure (pacing overdrive at 250 beats/min for 4-6 weeks)
Comparison
Isoproterenol vs Control/normal dogs
Design
Preclinical
Follow-up
4-6 weeks (pacing duration)
Authors
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Suggests velocity-force dissociation in canine HF despite receptor loss; leaves open human relevance and therapeutic implications.
Absolute Event Rate: 80% vs 122%
p-value: p=<0.001
In a canine model of pacing-induced heart failure, beta-adrenergic stimulation with isoproterenol normalizes myocardial shortening velocity but not force generation, despite reduced beta-adrenergic receptor density and signal transduction.
Juneau et al. (1992) studied Pacing-induced heart failure (n=48). Pacing overdrive vs. Unpaced controls was evaluated on Beta-adrenergic receptor density (fmol/mg) (p=<0.001). Pacing-induced heart failure in dogs decreased beta-adrenergic receptor density (80 vs 122 fmol/mg, P<0.001), but maximum unloaded velocity of shortening normalized in response to isoproterenol.
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