What question did this study set out to answer?

To evaluate the structural and functional progression of congestive heart failure and assess the capacity for myocardial recovery after discontinuing rapid pacing.

December 1, 1988Canadian Journal of Physiology and Pharmacology

Recovery from heart failure: structural and functional analysis in a canine model

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Why the study?

Does discontinuation of rapid ventricular pacing improve structural and functional parameters in a canine model of heart failure?

Population

15 dogs (9 paced to severe heart failure, 6 sham controls)

Comparison

Discontinuation of rapid ventricular pacing… vs Sham controls

Design

Preclinical

Follow-up

4 weeks

Authors

RHRobert HowardBrighton and Sussex Medical School TST P StoppsSt. Michael's Hospital GMGordon W. MoeHeart Failure & Transplant

Discussion

Member takes

Implication

Rapid systolic recovery but persistent dilation/hypertrophy in paced dogs; leaves open human reverse-remodeling timelines.

Key Points

To evaluate the structural and functional progression of congestive heart failure and assess the capacity for myocardial recovery after discontinuing rapid pacing.
Studied 15 dogs divided into rapid ventricular pacing at 250 beats/min to induce severe heart failure (n=9; duration 5.0 ± 1.8 weeks) and sham controls (n=6).
Monitored cardiac dimensions, hemodynamics, and area ejection fraction using serial two-dimensional echocardiography, followed by biochemical profiling and necropsy at 4 weeks of recovery.
Severe heart failure significantly increased diastolic cardiac area (11 ± 3 to 16 ± 2 cm², p < 0.05), reduced area ejection fraction (54 ± 8% to 21 ± 8%, p < 0.05), and induced left ventricular wall thinning (6.0 ± 0.7 to 4.7 ± 0.9 mm, p < 0.05).
Systolic performance and serum abnormalities normalized within 1 week of pacing cessation, but diastolic cardiac area remained significantly enlarged at 4 weeks (14 ± 3 cm² vs control, p < 0.05).
At 4 weeks of recovery, heart-to-body weight ratios indicated persistent hypertrophy compared with controls (9.4 ± 1.2 vs 7.7 ± 0.9 g/kg, p < 0.05), with normal histology and norepinephrine levels (617 ± 323 vs 676 ± 177 ng/g).

Structured PICO

Does discontinuation of rapid ventricular pacing improve structural and functional parameters in a canine model of heart failure?

Population

15 dogs (9 paced to severe heart failure, 6 sham controls)

Intervention

Discontinuation of rapid ventricular pacing (recovery phase) after 5.0 ± 1.8 weeks of pacing at 250 bpm

Comparator

Sham controls

Outcome

Structural and functional recovery assessed by echocardiography and necropsysurrogate

In a canine model of pacing-induced heart failure, discontinuation of pacing leads to rapid recovery of ventricular systolic performance but persistent diastolic enlargement and hypertrophy, indicating structural remodeling.

Cite This Study

Howard et al. (1988) studied this question.

synapsesocial.com/papers/6a7cc19210d8655be6fabbc6 https://doi.org/10.1139/y88-246

Topics

Heart failure HFrEF treatment Echocardiography Heart failure hospitalization

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Recovery from heart failure: structural and functional analysis in a canine model

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Recovery from heart failure: structural and functional analysis in a canine model

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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